BD (Becton, Dickinson and Company) has announced the publication of a peer-reviewed study that shows BD’s antigen test may be more selective than PCR (polymerase chain reaction) molecular tests at detecting people who are contagious and able to spread COVID-19 disease.
The leading global medical technology company said the study compared antigen and PCR test results to positive results using a viral cell culture test.
It further stated that viral growth in the cell culture test indicates the presence of live virus in the patient sample, which may indicate the presence of infectious virus at the time the sample was taken.
If no growth is present in the viral cell culture test, it is likely that there wasn’t enough viable virus for the patient to be contagious at the time the sample was taken.
Dr. Charles Cooper, study co-author and vice president of Medical Affairs for BD, said, “Point-of-care antigen tests, as demonstrated in this study with the BD Veritor™ Plus System, have the potential to significantly change the public health interventions needed to minimize the spread of COVID-19.”
He added: “By providing a more relevant test to identify individuals that are likely to be shedding infectious virus and therefore transmit SARS-CoV-2, we will be in a better position to contain its spread. Plus, the low cost and scalability of antigen-based testing makes it an important tool to contain and suppress COVID-19 community transmission.”
Cell culture technique
Out of 38 positive PCR result specimens tested, only 28 were positive using the cell culture technique. The antigen tests, conducted using the BD Veritor Plus System, were positive in 27 of the 28 cell culture positive tests.
This info suggests that 10 of the 38 PCR positive results were potentially identifying non-infectious individuals, meaning PCR detected viral RNA fragments or small amounts of intact SARS-CoV-2 virus and that the patient wasn’t actually contagious at the time the sample was taken.
But the BD antigen test agreed with all but one cell culture positive test. Diagnosing and isolating contagious people has been the primary goal for testing during the pandemic, followed by contact tracing and testing.
(With inputs from The OnLook News Research Bureau)
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