OncoSec announces first subjects dosed in Phase 1 trial of COVID-19 vaccine candidate

CORVax12 combines Interleukin-12 (IL-12) with an Enhanced SARS-CoV-2 Spike Protein; First-in-Class Combination Vaccine Using OncoSec's IL-12 DNA Plasmid-Based Cancer Immunotherapy with NIH's DNA Plasmid-Based Spike Protein


OncoSecOncoSec Medical Inc has announced that it has dosed several subjects in its Phase 1 clinical trial of CORVax12.

According to the company, it is the only vaccine candidate to include an immunostimulatory cytokine to address COVID-19.

Entitled CORVax12: SARS-CoV-2 Spike (S) Protein Plasmid DNA Vaccine Trial for COVID-19 (SARS-CoV-2)(NCT04627675), this trial will address safety and anti-viral immunological responses with the combination of a DNA-encodable stabilized SARS-CoV-2 spike glycoprotein and OnocSec’s cancer immunotherapy candidate, TAVO (tavokinogene telseplasmid), a potent and well-characterized plasmid-based IL-12 cytokine.

Christopher Twitty, Ph.D., Chief Scientific Officer of OncoSec, said, “Patients’ cancer, whether due to their immune status or anti-tumor therapy, may be unable to mount an effective immune response against COVID-19 via traditional vaccine approaches. As such, there remains a need to develop vaccine candidates (or combinations), such as CORVax12, so that patients do not lose precious time off therapy for an opportunity to be protected from COVID-19.”

Twitty added: “We are encouraged by the potential of CORVax12 as a next-generation vaccine to facilitate a long-lasting immune response. Immune compromised patients, such as those with cancer, may benefit from a vaccine option that not only drives an anti-tumor response, but also creates lasting immunity to SARS-CoV2 by boosting their immune systems to mount a defense against COVID-19. We joined the COVID-19 arena because we believe our IL-12 cancer immunotherapy and the spike protein vaccine approach may make a real impact for these patients.”

Similar to other current vaccines, CORVax12 expresses a stabilized SARS-CoV-2 spike protein which trains the immune system to recognize the virus that causes COVID-19.

Immune response

But the addition of IL-12 may augment the depth and type of immune response, which may enhance long-term anti-viral immunity. This coordinated cellular and humoral immunity is a hallmark of IL-12 and may not only provide for a better vaccine, but could significantly benefit patients with cancer who may not mount an effective immune response via a traditional vaccine approach.

Latest preclinical data on CORVax12 presented at the Society for Immunotherapy of Cancer (SITC)’s 35th Anniversary Annual Meeting demonstrated that CORVax12 induced a strong immune response in mouse models by leading to the production of anti-spike IgG antibodies capable of disrupting the receptor-binding domain of the spike protein.

In addition, preliminary preclinical data has demonstrated that CORVax12 administered into tumor tissue not only yields a productive anti-viral response, but also a strong anti-tumor response.

Trending News

(With inputs from The OnLook News Research Bureau)

If you like this article and if you feel it will be helpful for others to understand on the subject, please share it. You can also follow us on Twitter,  Facebook & Linkedin 

Also read: Research on preventative nasal spray reveals interesting results


Trending News